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El estudio inicial incluy a 301 pacientes de 22 centros, que recibieron seguimiento durante dos aos.

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Transaminase elevations were also observed in other placebo controlled studies in which exposure to Naltrexone hydrochloride at doses above the amount recommended for the treatment of alcoholism or opioid blockade consistently produced more numerous and more significant elevations of serum transaminases than did placebo.

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